Positron Emission Tomography Imaging of Dopamine Receptors Using the Tracer [11C]NNC-112
Status:
Completed
Trial end date:
2006-03-01
Target enrollment:
Participant gender:
Summary
This study will investigate the use of [11C]NNC-112 in positron emission tomography (PET)
scanning. PET is a technique that uses radioactive isotopes called tracers to provide images
of the brain. Injected into the body, the isotopes lose their "radioactive strength" over
time, sending out rays that can be picked up and "seen" by special detectors connected to a
computer. The computer then makes a picture of the brain. This study will examine the
distribution in the body of a new tracer called [11C]NNC-112.
Healthy normal volunteers between 18 and 70 years of age may be eligible for this study.
Candidates are screened with a physical examination and blood and urine tests, including a
urine drug screen. Women up to age 55 also have a pregnancy test.
Participants have a PET scan using the [11C]NNC-112 tracer. For this procedure, a catheter
(small plastic tube) is placed into a vein in the subject's arm for injecting the tracer.
Then, the subject lies on the scanner bed. After a preliminary "transmission scan," the
tracer is injected, and PET scans are taken from the head to the upper thigh over a period of
about 2 hours to show the distribution of radioactivity in the body. Blood pressure,
breathing rate, and heart rate are checked before and after injection of the tracer, and
blood and urine samples are collected after the PET scan.